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DTSTAMP:20250822T115804Z
LOCATION:Room 5.0B15 & 16
DTSTART;TZID=Europe/Stockholm:20250618T153000
DTEND;TZID=Europe/Stockholm:20250618T160000
UID:submissions.pasc-conference.org_PASC25_sess131_msa182@linklings.com
SUMMARY:Supercomputer-Based Multi-Physics and the Virtual Human Twin
DESCRIPTION:Caterina Balzotti and Mariano Vazquez (ELEM Biotech)\n\nThe us
 e of virtual human twins, powered by supercomputer-based multi-physics sim
 ulations, enables efficient and safe exploration of complex biomedical phe
 nomena. These digital replicas integrate high-fidelity physics-based model
 s to capture the complex interactions governing human physiology, offering
  new possibilities for understanding diseases and personalizing treatments
 . In this talk, we present our framework for high-fidelity cardiac modelin
 g, which integrates electrophysiology, mechanics, and blood flow dynamics 
 across multiple scales. Using the high-performance finite element solver A
 lya, developed at the Barcelona Supercomputing Center jointly with ELEM Bi
 otech, we demonstrate how these comprehensive models can be personalized w
 ith patient data to create virtual human populations. Our methodology enab
 les a detailed investigation of cardiac function in both healthy and patho
 logical conditions, providing a powerful platform for diverse clinical app
 lications, from evaluating the cardiac safety of drugs to analyzing how sp
 ecific diseases influence the heart’s electromechanical behavior.\n\nDomai
 n: Computational Methods and Applied Mathematics\n\nSession Chairs: Mauro 
 Bianco (ETH Zurich / CSCS, ETH Zurich) and Nur Aiman Fadel (ETH Zurich / C
 SCS)\n\n
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